ErbB Receptors

A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.

Also Known As:

EGF Receptor; EGF Receptors; Epidermal Growth Factor Receptor Family Proteins; Epidermal Growth Factor Receptor Kinase; HER Family Receptors; Proto-oncogene c-ErbB-1 Protein; Receptor Tyrosine-protein Kinase erbB-1; Receptor, ErbB-1; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; ErbB-1 Receptor; Family Receptor, HER; Family Receptors, HER; Proto oncogene c ErbB 1 Protein; Proto-Oncogene Protein, erbB-1; Receptor Tyrosine protein Kinase erbB 1; Receptor, ErbB; Receptor, ErbB 1; Receptor, HER Family; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha; Receptors, EGF; Receptors, Epidermal Growth Factor Urogastrone; Receptors, ErbB; Receptors, HER Family; c erbB 1 Protein; c-ErbB-1 Protein, Proto-oncogene; erbB 1 Proto Oncogene Protein; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Family Protein; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; ErbB Receptor; HER Family Receptor; Receptor, EGF; Receptor, Epidermal Growth Factor; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986
      - Peptide Receptors: 1159
        Growth Factor Receptors: 2663
        ErbB Receptors: 27986
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Receptor Protein-Tyrosine Kinases: 5999
        ErbB Receptors: 27986

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Disease

Drug/Important Bio-Agent (IBA)